Membrane fusion

fusion nature

Our former PhD student Jelger Risselada has performed large scale Martini simulations of SNARE-mediated membrane fusion and teamed up with experimentalists to explain how tethering proteins facilitate opening of the fusion pore. The exciting results are published in Nature:

M. D’Agostino, H.J. Risselada, A. Lürick, C. Ungermann, A. Mayer. A tethering complex drives the terminal stage of SNARE-dependent membrane fusion. Nature, doi:10.1038/nature24469