1. Force Fields
  3. Lipids
  5. Flip-flop in bilayer

normal Flip-flop in bilayer

  • dariush
  • dariush's Avatar Topic Author
  • Offline
  • Senior Boarder
More
10 years 3 weeks ago #3623 by dariush
Flip-flop in bilayer was created by dariush
Is there anybody, who observed flip-flop in the bilayer simulation using MARTINI? Pure bilayer or mixed one?
Could you please share the conditions?

Please Log in or Create an account to join the conversation.

More
10 years 3 weeks ago #3624 by helgi
Replied by helgi on topic Flip-flop in bilayer
Short, off the top of my head answer
No "normal" Martini lipids do not flip-flop on the few microsecond time scale without some bilayer defect / pore etc. But cholesterol does and so would specific "strange" lipids like e.g. diacylglycerols.

Cheers,
- Helgi

Please Log in or Create an account to join the conversation.

  • dariush
  • dariush's Avatar Topic Author
  • Offline
  • Senior Boarder
More
10 years 3 weeks ago #3625 by dariush
Replied by dariush on topic Flip-flop in bilayer
Thanks!
Is there any publication on this subject - using MARTINI? I found a paper, but it is full atomistic:

Replacing the cholesterol hydroxyl group by the ketone group facilitates sterol flip-flop and promotes membrane fluidity, T. Rog, L.M. Stimson, M. Pasenkiewicz-Gierula, I. Vattulainen, M. Karttunen, J. Phys. Chem. B. 112 1946-1952 (2008).

Please Log in or Create an account to join the conversation.

More
10 years 3 weeks ago - 10 years 3 weeks ago #3626 by mnmelo
Replied by mnmelo on topic Flip-flop in bilayer
Regarding cholesterol flip-flop:
pubs.acs.org/doi/abs/10.1021/ja076641c
pubs.acs.org/doi/full/10.1021/ja903529f (also AA)
Last edit: 10 years 3 weeks ago by mnmelo.

Please Log in or Create an account to join the conversation.

  1. Force Fields
  3. Lipids
  5. Flip-flop in bilayer
Time to create page: 0.105 seconds