Modeling Lipoprotein Particles
- Last Updated: Wednesday, 21 August 2013 11:39
Low-density and high-density lipoproteins (LDL/HDL) transport cholesterol in the bloodstream, and play an important role in the development of atherosclerosis. Despite their importance to health, their structure is not known in detail. They consist of a mixture of components including phospholipids, triglycerides, cholesterol, and associated proteins. The Martini model has proven useful to study the structure and dynamics of these particles.
Studies were originally performed on a model spheroidal HDL particle , focusing on the overal shape of the particle and the role of the associated apoA-I protein; subsequent studies  involved a more realistic lipid distribution inside HDL. Most recently the much larger LDL particle was investigated using the Martini model  (see figure).
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-  T.A. Vuorela, A. Catte, P.S. Niemela, A. Hall, M.T. Hyvonen, S.J. Marrink, M. Karttunen, I. Vattulainen. Role of lipids in spheroidal high density lipoproteins. PLoS Comp. Biol., 6:e1000964, 2010.
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