Whole Cell Model

We are now entering the era of whole-cell simulations. Together with the group of Zan Luthey-Schulten we already modeled an entire cell (JCVI-Syn3a) at the Martini level of resolution. Featuring more than 60,000 proteins, millions of lipids and metabolites, 500 ribosomes and a 500 kbp circular dsDNA, more than 500 million CG beads in total.

For details, read our perspective paper: Stevens et al., 'Molecular dynamics simulation of an entire cell', Frontiers in Chemistry, vol 11, 2023. https://doi.org/10.3389/fchem.2023.1106495

Martini-cell.jpg