- Last Updated: Saturday, 29 May 2021 08:25
Nanodisc technology is increasingly being applied for structural and biophysical studies of membrane proteins. Here you can find a general protocol for constructing nanodiscs for molecular dynamics simulations. The protocol is written in python and based on geometric equations, making it fast and easy to modify, enabling automation and customization of nanodiscs in silico. The tool allows one to efficiently construct any membrane scaffold protein (MSP) variant given only an input sequence.
The tool, developed by Lisbeth Kjølbye in the group of Birgit Schiøtt, can be found here: https://github.com/LHRK/Nanodisc-Builder
A paper describing the tool and showing examples of its validation is published in JCIM: https://pubs.acs.org/doi/10.1021/acs.jcim.1c00157