Nanopore for protein sequencing


Components from all three domains of life are used by the Maglia group to fabricate an integrated multiprotein complex that controls the unfolding and threading of individual proteins across a nanopore.

Multiscale models including Martini contributed to unravel the details of the structure and functioning of this megacomplex.

For details, see:  Zhang et al., Nature Chem. 2021.

Lipid nano-emulsions for drug delivery



Watch in molecular detail how vitamins are delivered to your skin !

Nice work from Machado et al., just published in Nanoscale.

Peripheral membrane proteins: (mostly) OK !

The Vanni lab performed a critical assessment on the performance of Martini 3 to model binding of peripheral proteins to membranes. Conclusion in short: Martini is "mostly able to correctly characterize the membrane binding behavior of peripheral proteins, and to identify key residues found to disrupt membrane binding in mutagenesis experiments", and "While preliminary, our investigations suggest that transferable chemical-specific CG force fields have enormous potential in the characterization of the membrane binding process by peripheral proteins, and that the identification of negative results could help drive future force field development efforts". Not bad at all ! For more details, see the full publication.

New Martini 3 tutorials

As part of the recent online Martini workshop, we developed a large number of new tutorials featuring the latest Martini 3 models. You can find the tutorials here, as well as a number of webinars on various aspects of Martini 3 and related tools. Enjoy !

New tools

ct1c00295_0009.gifct1c00322_0015.gifNew Martini tools are popping up like snails in my backyard, with the difference that the tools are welcome additions whereas the snails are not.

Check these papers for an updated backmapping tool from the Stansfeld group, and a brand new ATB from Miller and coworkers.